NEO-PEA-DOL 600™ 

Palmitoylethanolamide (PEA)+Bomelain        

60 Veggie-Caps bottle – 120 Veggie-Caps   bottle

NPN: 80083967

SUPPORTS RELIEF FROM OCCASIONAL PAIN AND SWELLING DISCOMFORT

• Effective relief from Joint &arthritis condition
• Provides natural relief for swelling discomfort
• Helps prevent damage caused by persistent inflammation
• Highly bioavailable Ultra micronized Palmitoylethanolamide + Bromelain

NEO-PEA-DOL 600™ contains a BIOACTIVE form of Palmitoylethanolamide (PEA), and Bromelain that have been studied for their benefits for inflammation condition. All these purest ingredients work together to help prevent abnormal inflammatory response and reducing swelling.

SUPPLEMENT FACTS

Serving Size: 1 Veggie Capsule

PEA (Micronized powder) Palmitoylethanolamide:  600 mg

Bromelain (2000 DGU/g):                                          10 mg

Equivalent at 24 000 FCC papain units per dose      

Non medicinal ingredients: Capsule: Microcrystalline cellulose, Hypermellose

SUGGESTED USE: For occasional pain and swelling discomfort

Recommended Dose: Take 1- veggie-capsule twice daily, or as directed by your health care professional.

Duration of Use: For use beyond 2 months, consult a health care practitioner.

Discussion:

Each Veggie-Capsule of NEO-PEA 600™ contains:

Palmitoyl Ethanolamide (PEA)

The discovery that palmitoylethanolamide, a member of the N-acylethanolamine family which is produced from the lipid bilayer on-demand, is capable of exerting antiallodynic and anti-hyperalgesic effects by down-modulating both microglial and mast cell activity has led to the application of this fatty acid amide in several clinical studies of neuropathic pain, with beneficial outcome and no indication of adverse effects at pharmacological doses.

Collectively, over 3000 research studies have confirmed that palmitoylethanolamide act as a disease-modifying agent for controlling inflammatory responses and related chronic and neuropathic condition.

PEA: mechanism(s) of action

The mechanism(s) underlying PEA action in NP remain to be fully defined. PEA, however, appears to function as an anti-inflammatory and pain-reliever with more than one ‘‘modus operandi’’, and able to modulate the ‘‘endocannabinoidome’’ in a safer and more therapeutically efficacious way (Maione et al. 2013). In 2005, the transcription factor peroxisome proliferator activated receptor alpha (PPAR-a) was identified as one possible target mediating the anti-inflammatory actions of PEA (LoVerme et al. 2005a, b).

-Bromelain (2000 DGU/gr)

Bromelain is derived from the stem of the pineapple plant (Ananas comosus).1

The pineapple protease, bromelain, selectively inhibits the biosynthesis of proinflammatory prostaglandins, apparently by indirect action.

Experimental and clinical studies reveal that Bromelain exhibits anti-inflammatory properties, which include:

1. a) Inhibition of the biosynthesis of pro-inflammatory prostaglandins and induction of prostaglandin E1 (which tends to inhibit inflammation)
2. b) Activation of proteolytic activity at sites of inflammation and fibrinolysis activity via the plasminogen-plasmin system (Bromelain stimulates the conversion of plasminogen to plasmin, which in turn activates fibrinolytic activity, dissolving fibrin-based clots and reducing swelling).
3. c) Bromelain has also been shown to reduce plasma kininogen levels, which inhibits the production of kinins. Kinins are known to cause inflammation, swelling and pain.

CAUTION: Consult a health care practitioner if symptoms persist or worsen. If you are pregnant or breastfeeding, If you have a gastrointestinal lesion/ ulcer, are taking an anticoagulant/ blood thinner, anti-inflammatory or antibiotic, or are having surgery, consult a health care practitioner prior to use.

Contraindications:

(With Bromelain) Mild gastrointestinal symptoms (nausea, vomiting, or cramping) or rare allergic reactions have been known to occur in which case, discontinue use.

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